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It functions by mimicking the actions of GLP-1, which transmits a satiety signal to the brain, thereby diminishing hunger and resulting in reduced calorie consumption

The Studys Limitations Are Not Minor The authors are appropriately careful in their conclusions

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In addition, increased mTOR activation leads to adipogenesis which can lead to obesity-mediated insulin resistance

So, while a temporary rise in blood sugar post-administration is expected, it does not automatically equate to long-term insulin resistance

PMID: 27847966 | doi:10.1007/s00109-016-1488-y Chang CH et al